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NFL Week 6: Matchup Previews, Predictions, and Picks
Confirmed
In Short: Experts offer their insights and predictions for NFL Week 6 games, including key matchups and betting tips.

NFL Week 6 features a slate of games culminating with the Monday Night Football matchup between the Commanders and 49ers on ESPN.
Atlanta ranks fourth in rushing yards allowed per game (80.2), while Chicago ranks ninth (96.0).
ESPN's Football Power Index (FPI) provides game projections, and analysts Seth Walder, Eric Moody, and Pamela Maldonado offer their final score picks and insights for each game.
Rome Odunze praised quarterback Caleb Williams' talent, noting his arm ability and playmaking skills.
Williams' potential return from a hamstring injury could inject explosiveness into the Bears' offense.
The Thursday Night Football matchup between the Seahawks and Broncos is a marquee event, with the Bills and Raiders also facing off on Sunday.
Week 6 includes five divisional matchups, with high-stakes games like the Rams and 49ers playing in Australia.
The matchup between the Falcons and Saints on Monday Night Football is a highlight, with intra-division showdowns between the Chiefs and Raiders, and an NFC South matchup.
Experts are closely watching the performance of the Rams and 49ers after their game in Australia.
The matchup between Cincinnati cornerback Dax Hill and Jacksonville wide receiver Parker Washington is a key focus.
Chicago could benefit significantly from Williams' return, particularly with his deep ball capabilities and play under pressure.
What this adds
This week's coverage builds on previous NFL expert analyses and predictions for Week 5 games.
The full schedule includes games on Thursday, Sunday, and Monday, with a variety of matchups and betting angles.
Background
NFL experts provide their picks and predictions for Week 5 games, including key matchups and betting insights.
What's confirmed
- NFL Week 6 features a slate of games culminating with the Monday Night Football matchup between the Commanders and 49ers on ESPN.
- Atlanta ranks fourth in rushing yards allowed per game (80.2), while Chicago ranks ninth (96.0).
- ESPN's Football Power Index (FPI) provides game projections, and analysts Seth Walder, Eric Moody, and Pamela Maldonado offer their final score picks and insights for each game.
- Rome Odunze praised quarterback Caleb Williams' talent, noting his arm ability and playmaking skills.
- Williams' potential return from a hamstring injury could inject explosiveness into the Bears' offense.
- The Thursday Night Football matchup between the Seahawks and Broncos is a marquee event, with the Bills and Raiders also facing off on Sunday.
- Week 6 includes five divisional matchups, with high-stakes games like the Rams and 49ers playing in Australia.
- The matchup between the Falcons and Saints on Monday Night Football is a highlight, with intra-division showdowns between the Chiefs and Raiders, and an NFC South matchup.
- Experts are closely watching the performance of the Rams and 49ers after their game in Australia.
- The matchup between Cincinnati cornerback Dax Hill and Jacksonville wide receiver Parker Washington is a key focus.
- Chicago could benefit significantly from Williams' return, particularly with his deep ball capabilities and play under pressure.
What's still developing
- Let's get into the full Week 6 slate, which culminates with the "Monday Night Football" matchup between the Commanders and 49ers on ESPN. (Game times are Sunday unless otherwise noted, and all odds are via DraftKings.) Jump to a matchup: HOU-JAX | CHI-ATL | BAL-CLE TEN-IND | NYJ-NE | NO-NYG CAR-PHI | PIT-TB | ARI-LAR LAC-KC | BUF-LV | DAL-GB WSH-SF Thursday: SEA-DEN Bye: CIN, DET, MIA, MIN 9:30 a.m.
- "So obviously, when you're missing a player like that on the field, you feel it."
- Then, analytics writer Seth Walder makes a bold prediction for each matchup, fantasy analyst Eric Moody shares fantasy football intel, and betting analyst Pamela Maldonado gives her insights for each contest.
- Stroud will have an opportunity to re-create their fireworks from their college stint at Ohio State in 2021-22.
- "It’s worth noting ahead of this Week 2 matchup that the Ravens might be without both Zay Flowers (hamstring) and Ja’Kobi Lane (fractured wrist) in this game, putting real restraints on this passing game. That creates an avenue for New Orleans to win, but we think Jackson and Henry ultimately run their way to a 2-0 record against a defense that allowed 165 yards and 5 ypc in Week 1."
- 🎙 UPCOMING BROADCASTS - SUNDAY: 11:45 AM ET, PATRIOTS PREGAME SHOW; AFTER GAME, POSTGAME SHOW & PRESS CONFERENCE COVERAGE Forged in Foxborough Episode 3: Earn Your Role Experts share their picks for the Patriots' Week 2 matchup against the Pittsburgh Steelers.
- Here are the four series that begin Sunday, Sept. 27: At the time of publication, the WNBA has yet to assign television slots for the Game 1s.
- Not only did the lower-seeded Liberty win the season series 2-1, with the most recent win coming approximately one week ago, but some might even suggest that the Lynx “strategically” attempted to avoid this matchup, whereas the Liberty were aiming for it.
- ET on ABC, with another Game 1 immediately following on ABC at 4 p.m.
- The biggest matchup of the weekend takes place right out of the gate on Saturday afternoon, with Arch Manning and the No.
- There’s a blockbuster matchup during each timeslot, so prepare to be glued to your television for the entire day.
- After we kicked off the new season last week, Week 2 promises to carry the baton with a number of high-stakes games on the docket, including five divisional matchups.
