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NFL Experts Offer Week 5 Picks, Predictions
Confirmed
In Short: NFL experts provide their picks and predictions for Week 5 games, including key matchups and betting insights.

NFL experts are offering their picks and predictions for Week 5, with a slate of games that includes high-profile matchups and potential upsets.
In a Thursday night game, the Dallas Cowboys face the Tampa Bay Buccaneers. Experts are skeptical of the Buccaneers' chances, given their undrafted rookie quarterback, but some see potential for a close game due to the Cowboys' struggling defense.
The Indianapolis Colts are favored to win against the Pittsburgh Steelers, with a prediction of a 20-16 victory. The Colts' Jonathan Taylor and the Steelers' defensive struggles are key factors in this prediction.
The Minnesota Vikings are favored to win against the New Orleans Saints, with a prediction of a 24-17 victory. The Vikings' strong start and the Saints' resurgent offense make this a closely watched game.
The Denver Broncos are favored to win against the Jacksonville Jaguars, with a prediction of a 23-20 victory. The Jaguars' recent blowout win over Cleveland and the Broncos' loss to the Chiefs are factors in this matchup.
Experts are also predicting a 100-yard receiving night for CeeDee Lamb against the Buccaneers, despite the Buccaneers' strong defensive performance so far this season.
What this adds
The model at SportsLine is up over $7,000 for $100 players on top-rated NFL picks since its inception.
Background
ESPN's preview of the Week 4 games includes bold predictions and fantasy insights for each matchup.
CBS Sports experts predict the Dodgers and Yankees will dominate their respective playoff series, with the Dodgers favored over the Braves and the Yankees over the Rays.
What's confirmed
- NFL experts are offering their picks and predictions for Week 5, with a slate of games that includes high-profile matchups and potential upsets.
- In a Thursday night game, the Dallas Cowboys face the Tampa Bay Buccaneers. Experts are skeptical of the Buccaneers' chances, given their undrafted rookie quarterback, but some see potential for a close game due to the Cowboys' struggling defense.
- The Indianapolis Colts are favored to win against the Pittsburgh Steelers, with a prediction of a 20-16 victory. The Colts' Jonathan Taylor and the Steelers' defensive struggles are key factors in this prediction.
- The Minnesota Vikings are favored to win against the New Orleans Saints, with a prediction of a 24-17 victory. The Vikings' strong start and the Saints' resurgent offense make this a closely watched game.
- The Denver Broncos are favored to win against the Jacksonville Jaguars, with a prediction of a 23-20 victory. The Jaguars' recent blowout win over Cleveland and the Broncos' loss to the Chiefs are factors in this matchup.
- Experts are also predicting a 100-yard receiving night for CeeDee Lamb against the Buccaneers, despite the Buccaneers' strong defensive performance so far this season.
What's still developing
- They allowed a grand total of 17 rushing yards to the Cincinnati Bengals ' running backs last week and are tied for second in takeaways with eight. … Prediction: Jaguars 27, Eagles 18 Dubin (Eagles +7): I don't exactly feel great about this prediction given the way the Eagles have looked so far this season, but I'm betting that they can at least keep the game relatively close against a Jaguars team that looks like one of the best in football.
- This week, the Philadelphia Eagles and Jacksonville Jaguars face off in London, the San Francisco 49ers will play the reigning Super Bowl champion Seahawks in Seattle, and Josh Allen takes on Matthew Stafford on "Monday Night Football." There were 23 games decided by one score over the past two weeks, which is tied for the most in a two-week span in NFL history.
- The Eagles blew a 10-point lead to the Los Angeles Rams in the final four minutes of the fourth quarter last Sunday, and went an incredible 0-12 on third downs.
- That's probably because he's got an MVP candidate next to him in Bijan Robinson, who is off to a historic start, averaging 153.5 total yards per game.
- The Colts also have a fairly friendly defense, but I frankly don't trust the Steelers as far as Aaron Rodgers or I can throw them, so I'm taking the Colts to win a low-ish scoring game on the back of Jonathan Taylor. … Prediction: Colts 20, Steelers 16 Dubin (Seahawks -2.5): I think these look like the two best teams in the league so far this season, despite Seattle's weird loss to Washington and the let-up the defense showed in the second half against L.A. last week.
- Cowboys on “Thursday Night Football.” It’s already Week 5, and the slate of games kicks off with a Thursday night matchup between two teams perhaps headed in very different directions.
- This was one week where we all had to hem and haw over the majority of picks on the slate, because there are so many unknowns in Week 5 — and also some serious desperation games.
- The panel rolls out with their picks in Week 5, and this is a DOOZY of a schedule around the NFL.
- "I know the Buccaneers have no business keeping it close on a short week, in Dallas, and with an undrafted rookie at quarterback. Short-week games can be weird, though, and it's already been a strange season. Really, this isn't as much of a mismatch on paper as it might seem. Dallas' defense is still quite bad and has struggled against both the run (31st) and the pass (24th). If Jalon Daniels can avoid turnovers and make the most of his scrambling ability, the Bucs might even make this one uncomfortably close for the Cowboys."
- I strongly suggest you check out the Week 5 NFL Betting Hub, where you’ll find all of the features and picks from my talented co-workers.
- MORE: Check out our Pro Picks page for NFL best bets from all of our analysts There probably won’t be anything fun about waking up and backing a life-less Eagles team, but it feels like it must be done.
- Let's see who the experts are picking to win the game: Vikings 24, Saints 17 – Pete Prisco, CBS Sports Saints 23, Vikings 19 – Bill Bender, Sporting News The Vikings are 4-0 and road favorites against a resurgent New Orleans offense coming off a short week.
Sources
- CBS Sportslink
- Pride Of Detroitlink
- Sbnationlink
- Tampa Bay Buccaneerslink
- VSiNlink
- Vikings.comlink
- Atlantafalconslink
- Foxsportslink
- CBS Sportslink
- Sportslinelink
- Warpbeatlink
- Bleacherreportlink
- Fantasyalarmlink
- Steelcurtainnetworklink
- WarpBeat — background on Our guide to every Week 4 game: Matchup previews, predictions, picks link
- WarpBeat — background on 2026 MLB playoff predictions: Expert picks for Dodgers vs. Braves, Yankees vs. Rays and every LDS matchup link
- USA TODAY Sports — video link
