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15 predictions for this weekend's NFL games: We picked upsets, sleepers, TD scorers and more
Confirmed
In Short: Fantasy football analysts and NFL experts predict upsets, sleeper picks, and top performers for the upcoming games.
Fantasy football writer Eric Moody and analyst Matt Bowen from ESPN suggest sleepers and players who will find the end zone in Week 2.
Moody highlights three sleepers, while Bowen predicts three players who will score touchdowns.
Ben Solak, another ESPN analyst, offers three wild-card predictions for the weekend.
The Denver Broncos are favored to beat the San Francisco 49ers, but with the 49ers missing key player Nick Bosa, the game could be closer than expected.
CBS Sports' Pete Prisco predicts the Jacksonville Jaguars will upset the Denver Broncos, citing the Broncos' recent loss to the Chiefs and the Jaguars' strong performance against them last December.
Prisco also predicts the Indianapolis Colts will keep the Kansas City Chiefs close, despite the Chiefs' strong running game.
USA Today's expert analysis suggests the Baltimore Ravens will run their way to a 2-0 record against a defense that struggled in Week 1.
Pete Prisco also predicts the Los Angeles Chargers will bounce back against the Las Vegas Raiders, emphasizing the Chargers' need for a win after a recent embarrassing loss.
The Week 2 slate features high-stakes games, including five divisional matchups, giving fans plenty of opportunities to bet on the NFL.
What this adds
The predictions cover a range of games, from upsets to sleeper picks, providing a comprehensive guide for fans and bettors.
What's confirmed
- Fantasy football writer Eric Moody and analyst Matt Bowen from ESPN suggest sleepers and players who will find the end zone in Week 2.
- Moody highlights three sleepers, while Bowen predicts three players who will score touchdowns.
- Ben Solak, another ESPN analyst, offers three wild-card predictions for the weekend.
- The Denver Broncos are favored to beat the San Francisco 49ers, but with the 49ers missing key player Nick Bosa, the game could be closer than expected.
- CBS Sports' Pete Prisco predicts the Jacksonville Jaguars will upset the Denver Broncos, citing the Broncos' recent loss to the Chiefs and the Jaguars' strong performance against them last December.
- Prisco also predicts the Indianapolis Colts will keep the Kansas City Chiefs close, despite the Chiefs' strong running game.
- USA Today's expert analysis suggests the Baltimore Ravens will run their way to a 2-0 record against a defense that struggled in Week 1.
- Pete Prisco also predicts the Los Angeles Chargers will bounce back against the Las Vegas Raiders, emphasizing the Chargers' need for a win after a recent embarrassing loss.
- The Week 2 slate features high-stakes games, including five divisional matchups, giving fans plenty of opportunities to bet on the NFL.
What's still developing
- No more cushy series of all home games for the higher seeds.
- The Week 5 college football schedule features nearly 60 total games, giving you plenty of opportunities to take advantage of the best sportsbook promo codes to boost your bankroll by nearly $3,000 for college football betting.
- Let's make 15 big predictions for the Sunday and Monday action.
- Jump to: Upset picks | Projected stat lines Fantasy sleepers, surprises TD scorers | Other predictions Denver Broncos +3 (+124 moneyline) at San Francisco 49ers Broncos quarterback Bo Nix 's production drops sharply under pressure, but the 49ers will be without edge rusher Nick Bosa ( calf ) in Week 4.
- But the Week 2 slate is also littered with games featuring teams looking to get off to a 2-0 start or avoid an 0-2 start.
- Though the Chicago Bears and Houston Texans each qualified for the postseason last year after losing their first two games, only 35 of 288 teams since 1990 had recovered from an 0-2 start to make the playoffs prior to the 2025 season, according to the NFL.
- Here's a look at the early expert picks, predictions and odds for every game during Week 2 of the 2026 NFL season : Odds courtesy of BetMGM as of Tuesday, Sept.
- Check out our soccer expert’s Real Madrid vs Inter Milan predictions and betting tips, prior to Tuesday’s 3pm ET Champions League clash (09/08).
- Additionally, Real Madrid have scored at least once in 35 of their 36 UCL games under Mourinho’s guidance.
- Four of their last five European games at the Santiago Bernabeu produced exactly three goals.
- Three of Real’s last four games saw the goal count exceed two, which is highly likely here.
- Consider college football legend Nick Saban among the non-believers regarding quarterback Sam Leavitt's status ahead of this weekend's huge game.
