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OFC Delabels Peanut Allergy in Over a Third of Infants
Developing
In Short: The study, published in The Journal of Allergy and Clinical Immunology: In Practice, analyzed medical records from multiple hospital sites.
Researchers from the Murdoch Children's Research Institute found that among infants under 18 months with a prior peanut reaction and evidence of sensitization, more than a third had a negative challenge, allowing immediate delabeling and regular peanut consumption.
Perrett, MBBS, PhD, the corresponding author, emphasized the importance of accurately confirming allergies in infants to reduce the burden of misdiagnosis on patients and families.
Some hospitals prioritized infants less likely to react or whose families wanted to start oral immunotherapy (OIT), while the proportion of eligible infants who underwent the challenge varied across hospitals.
The study was supported by the National Allergy Centre of Excellence, funded by the Australian government and philanthropic support to the Murdoch Children's Research Institute.
What's still developing
- "We strongly recommend considering this approach for diagnosis of peanut allergy in infants regardless of whether OIT or an allergen avoidance strategy is being pursued," the authors wrote.
- This was a retrospective analysis of medical records collected across multiple hospital sites, and the proportion of eligible infants who underwent the challenge differed across hospitals.