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Nick Bosa to Miss Multiple Games Due to Calf Injury
Confirmed
In Short: San Francisco 49ers defensive end Nick Bosa will miss multiple games after suffering a calf injury during Thursday's practice, according to NFL insider Adam Schefter.
Bosa, 28, had played in the team's first two games this season, contributing seven combined tackles, three solo tackles, two tackles for a loss, and one quarterback hit.
The injury is a significant blow to the 49ers' defense, which ranks ninth in pass defense, allowing just 175 yards per game.
Bosa's status for Sunday's game against the Arizona Cardinals is uncertain, with sources indicating he may miss a few weeks.
Bosa's injury is the latest in a series of setbacks for the 49ers' defensive line, which has already faced challenges this season.
Returning from a torn ACL in his right knee, Bosa had played only 70 snaps in the first two weeks of the season.
The 49ers are still determining whether Bosa needs to be placed on injured reserve, which would sideline him for a minimum of four games.
Bosa's absence could impact the team's chances of continuing its winning streak, as he is considered one of the NFL's elite edge rushers.
The team's next four games are against the Cardinals, Denver Broncos, Seattle Seahawks, and Washington Commanders.
Keion White and Khalid Kareem are the two healthy defensive ends and will need to step up in Bosa's absence.
In eight seasons, Bosa has 285 total tackles with 64.5 sacks, 13 forced fumbles, five fumble recoveries, and two interceptions in 87 games, 85 of which were starts.
What this adds
The extent of Bosa's injury and whether he will be placed on injured reserve remains unclear.
The 49ers' defense will need to adjust its strategy without Bosa's contributions for the upcoming games.
What's confirmed
- Calif. -- San Francisco 49ers defensive end Nick Bosa suffered a calf injury in practice Thursday that is expected to cost him a few weeks, sources told ESPN's Adam Schefter and NFL Network's Ian Rapoport on Friday.
What's still developing
- Bosa, 28, played in his team's win over the Los Angeles Rams to start the season in Australia, and again this past Sunday in a victory over the struggling Miami Dolphins.
- According to NFL insider Adam Schefter, Bosa pulled his calf at Thursday's practice, leading to his latest injury issue.
- However, he didn't practice ahead of the team's Week 3 game against the Arizona Cardinals, and now there is concern about his availability for multiple games.
- On Friday morning, NFL insider Ian Rapoport shared that Bosa suffered a calf injury in practice this past week and may miss a "few weeks" with the San Francisco 49ers.
- More news: Lions’ Amon-Ra St Brown Has Blunt Reaction to Hefty NFL Celebration Fines Bosa's status for Sunday's game was listed as "unspecified" on the 49ers' injury report.
- In Week 3 of the 49ers' 2025 season, Bosa suffered a torn ACL and has continued to deal with lingering tendonitis and a knee condition.
- He was listed as a nonparticipant for Wednesday's practice with the designation of "resting player/knee," but the 49ers added the calf to the knee designation Thursday and Bosa did not practice or do his usual weekly media session on Wednesday or Thursday.
- Bosa suffered a torn ACL during Week 3 of last season, ending his 2025 campaign.
- Bosa has spent his entire career with the 49ers, beginning his NFL journey in 2019 as a second overall pick.